Aztreonam/avibactam

Aztreonam/avibactam
Combination of
Aztreonamβ-lactam antibiotic
Avibactamβ-Lactamase inhibitor
Clinical data
ATC code
  • None
Legal status
Legal status
  • Investigational

Aztreonam/avibactam is a combination of aztreonam and avibactam developed by AbbVie for "complicated Gram-negative infections".[1][2][3] Drug resistance to the combination has been reported.[4]

Society and culture

In March 2024, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Emblaveo, intended for the treatment of complicated intra-abdominal and urinary tract infections, hospital-acquired pneumonia and infections due to aerobic Gram-negative organisms in people with limited treatment options.[5] The applicant for this medicinal product is Pfizer Europe MA EEIG.[5]

References

  1. ↑ "Pipeline". AbbVie. Retrieved 25 November 2023.
  2. ↑ Sader, Helio S; Castanheira, Mariana; Kimbrough, John H; Kantro, Valerie; Mendes, Rodrigo E (22 March 2023). "Aztreonam/avibactam activity against a large collection of carbapenem-resistant Enterobacterales (CRE) collected in hospitals from Europe, Asia and Latin America (2019–21)". JAC-Antimicrobial Resistance. 5 (2): dlad032. doi:10.1093/jacamr/dlad032. ISSN 2632-1823. PMC 10032302. PMID 36968952.
  3. ↑ Livermore, David M.; Mushtaq, Shazad; Vickers, Anna; Woodford, Neil (May 2023). "Activity of aztreonam/avibactam against metallo-β-lactamase-producing Enterobacterales from the UK: Impact of penicillin-binding protein-3 inserts and CMY-42 β-lactamase in Escherichia coli". International Journal of Antimicrobial Agents. 61 (5): 106776. doi:10.1016/j.ijantimicag.2023.106776. PMID 36893810. S2CID 257428399.
  4. ↑ Nordmann, Patrice; Yao, Yancheng; Falgenhauer, Linda; Sadek, Mustafa; Imirzalioglu, Can; Chakraborty, Trinad (18 October 2021). "Recent Emergence of Aztreonam-Avibactam Resistance in NDM and OXA-48 Carbapenemase-Producing Escherichia coli in Germany". Antimicrobial Agents and Chemotherapy. 65 (11): e0109021. doi:10.1128/aac.01090-21. PMC 8522741. PMID 34424048. S2CID 237268078.
  5. 1 2 "Emblaveo EPAR". European Medicines Agency. 21 March 2024. Retrieved 23 March 2024. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.


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