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Two by Two, two by two, 2×2 or 2by2 may refer to:
Arts, entertainment and media
Film and television
- 2×2 (TV channel), a TV channel in Russia
 - Two by Two, or Ooops! Noah Is Gone..., a 2015 animated film
 - "Two By Two", a Rugrats TV episode
 
Music and musicals
- Two by Two (musical), a 1970 Broadway show with music by Richard Rodgers
 
Albums
- Two by Two (album), by Blue Zoo, 1983
 - 2×2, a box set of the albums All or Nothing and The U.S.-Remix Album: All or Nothing by Milli Vanilli released in the UK and France in 1989
 - 2 X 2, a 1997 album by Gigi
 - II x II, a 1970 album by The Cowsills
 
Songs
- "Two by Two", from the musical The Book of Mormon
 - "Two By Two", a song by Quasi from the 1999 album Field Studies
 - "2 X 2", a song by Bob Dylan from the 1990 album Under the Red Sky
 - Two by Two, a 1988 song by Cristiana Cucchi
 
Other uses
- 2x2, a two-wheeled two-wheel drive vehicle
 - 2by2, an American lottery game
 - 2x2 Project, a public health journalism initiative
 - Two-by-two matrix, a square matrix of order 2
 
See also
- Two (disambiguation)
 - 2+2 (disambiguation)
 - Two two (disambiguation)
 - Pocket Cube, a puzzle device also known as a 2×2×2 Rubik's Cube
 - Two by Twos, a religious movement
 
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