Arkham is a fictional city in Massachusetts created by H. P. Lovecraft.
Arkham may also refer to:
- Arkham Asylum, a fictional psychiatric hospital in the DC Comics Universe
- Amadeus Arkham, the founder of Arkham Asylum
- Jeremiah Arkham, the current fictional head of Arkham Asylum
- Arkham (Devil May Cry), one of the main antagonists in the Devil May Cry video game series
- Batman: Arkham, a series of video games set in the Batman universe
- "Arkham" (Gotham), a television episode
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