Breña is a district, Lima, Peru. Breña or Brena may also refer to:
- Brena (surname)
 - "Breña", a song by A Perfect Circle from Mer de Noms
 - Breña Alta, a municipality in the province of Santa Cruz de Tenerife, in the Canary Islands
 - Breña Baja, a municipality in the province of Santa Cruz de Tenerife, in the Canary Islands
 - Las Breñas, a city in Chaco Province, Argentina
 - House at Breñas Point, a house on a peninsula named Breñas, in Dorado, Puerto Rico
 - Brena (footballer) (born 1996), Brazilian footballer
 
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