Esco or ESCO may refer to:
Places
- Esco, Kentucky, an unincorporated community in the US
 - Escó, a village in Spain
 - Escos, a commune in France
 
Organizations
- Energy service company or energy savings company (ESCO or ESCo)
 - ESCO Corporation, a manufacturer of engineered metal parts and components
 - ESCO Foundation for Palestine, a private family foundation set up in 1940
 - Esco (Singaporean company) that develops, manufactures, and sells products and services for laboratories
 - Estonian Shipping Company, a Soviet Union- (and later Estonia-) based shipping company
 - Esco Trading, an arcade game company founded by Hayao Nakayama in 1967 and purchased by Sega in 1979
 
Other uses
- Esco (name)
 - ESCO - European Skills, Competences, Qualifications and Occupations, a multilingual classification of identifies and categorises skills, competences, qualifications and occupations relevant for the EU labour market and education
 - eSCO, a Bluetooth protocol for transmitting voice data
 - ESCO1, or establishment of sister chromatid cohesion N-acetyltransferase 1, a protein that in humans is encoded by the ESCO1 gene
 - ESCO2, an enzyme that in humans is encoded by the ESCO2 gene
 
See also
- Escondido, California, a city in California, US
 
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