Greenspan is a typically Ashkenazi Jewish surname. It is the anglicized form of the German/Yiddish surname Grünspan ("green swarf", "green patina", "verdigris", "copper(II) acetate"). Cognate are the surnames Grynszpan, Grinszpan and Grinshpan (Poland, Romania, Hungary).
Notable people with the surname include:
- Alan Greenspan (born 1926), American economist, former Federal Reserve Chairman
 - Alison Greenspan (1972–2021), American film and television producer
 - Bennett Greenspan (born 1952), American entrepreneur, founder of Family Tree DNA
 - Brad Greenspan (born 20th century), American entrepreneur (MySpace)
 - Brian Greenspan (born 1947), Canadian lawyer
 - Bud Greenspan (1926–2010), American film director
 - David Greenspan (born 1956), American actor and playwright
 - Dorie Greenspan (born 20th century), American author of cookbooks
 - Edward Greenspon (born 1957), Canadian newspaper editor
 - Harvey P. Greenspan (born 1933), American mathematician
 - Herschel Grynszpan (1921-before 1945), Jewish assassin
 - Jason Scott Greenspan (born 1959), aka Jason Alexander, American actor
 - Jerry Greenspan (1941–2019), American basketball player
 - Marshall Greenspan, American engineer
 - Mauro Cabral Grinspan, (born 1971), Argentinian intersex and trans activist
 - Melissa Greenspan (born 20th century), American actress
 - Nachman Shlomo Greenspan (1878–1961), Polish-born UK rabbi and Talmudic scholar
 - Natan Grinszpan-Kikiel, birth name of Roman Romkowski, state security official in Communist Poland
 - Ryan Greenspan (born 1982), American paintball player
 - Stanley Greenspan (1941–2010), American psychiatrist
 
See also
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