Guardado is a Spanish surname, which derives from guardar, meaning "to guard". It may refer to:
- Albert Guardado (born 1973), American boxer
- Andrés Guardado (born 1986), Mexican football player
- Eddie Guardado (born 1970), American baseball player
- Emilio Guardado, Salvadoran football coach
- Mark Guardado (1961–2008), American mobster
- Oscar Whalley Guardado
See also
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