IRF may refer to:
General
- Impulse response function
- Inertial reference frame
- Information Retrieval Facility
- Initial Reaction Force or Internal Response Force
- Immediate Response Force
- Institute of Space Physics (Sweden), (Institutet för rymdfysik)
- Interferon Regulatory Factor (e.g. IRF6)
- International Rectifier, New York Stock Exchange symbol IRF
Foundations/organizations
Computing
- Intelligent Resilient Framework, Virtual Switch Chassis Aggregation
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