John Culpepper was an American politician.
John Culpepper, Culpeper or Colepeper may also refer to:
- John Colepeper, 1st Baron Colepeper (c. 1600–1660), English Royalist landowner, military adviser, politician, Chancellor of the Exchequer, Master of the Rolls and influential counsellor of King Charles I during the English Civil War
 - John Culpeper (died 1414), English knight
 - John Culpeper, leader of Culpeper's Rebellion in 1677 in the province of Carolina in North America
 - J. Broward Culpepper, John Broward Culpepper (1907–1990), influence on university education in Florida
 - Brad Culpepper, John Broward Culpepper (born 1969), American National Football League player
 - John Culpepper (MP) for Rutland (UK Parliament constituency)
 
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