La Leona may refer to:
- La Leona (guitar), a famous guitar owned by Miguel Llobet
- La Leona, Costa Rica, a small town in Costa Rica
- La Leona, Texas, a small settlement in Texas, USA
- Paseo La Leona, a pass in Honduras
- Parque La Leona, a park in Honduras
- La Leona River, a river in Argentina
- La Leona (film), a 1964 Argentine film
- La Leona (Argentine telenovela), an Argentine telenovela that aired in 2016
- La Leona (Mexican telenovela), a telenovela that aired in 1961
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