Marble is the surname of:

• Alexander Marble (1902–1992), American medical doctor and diabetologist
• Alice Marble (1913–1990), American tennis player
• Dan Marble (1810–1849), American comedic actor
• Devyn Marble (born 1992), American basketball player
• Edward Marble (1846–1900), American actor and songwriter, son of Dan Marble
• Ella M. S. Marble (1850-1929), American physician
• Frank E. Marble (1918–2014), American engineer and scientist in the field of aerodynamics and combustion
• Harmon Percy Marble (1870–1945), American journalist and politician, mayor of Las Vegas
• Harriet Marble (1885–1966), African-American woman pharmacist, the first in Kentucky
• John Hobart Marble (1869–1913), American attorney and government official
• Manton Marble (1835–1917), American journalist, proprietor and editor of the New York World newspaper from 1860 to 1876
• Roy Marble (1966–2015), American basketball player
• Scott Marble (1847–1919), American playwright
• Sebastian Streeter Marble (1817–1902), American politician, governor and state senator of Maine
• Vicki Marble (fl. 2010s), American politician and Colorado state senator
• Webster Marble (1854–1930), American inventor and entrepreneur