Mineo is both an Italian surname and a masculine Japanese given name. Notable people with the name include:
Surname
- Alfred Mineo (1880–1930), American Mafia Godfather, leader of the family that became the Gambino crime family
 - Settimo Mineo (born 1938), Italian mobster
 - Sal Mineo (1939–1976), American film and stage actor
 - Ted Mineo (born 1981), American artist
 - Andy Mineo (born 1988), American rapper
 
Given name
- Mineo Ōsumi (大角 岑生, 1876–1941), Japanese politician and Commander of the Japanese Navy during World War II
 - Mineo Yoshikawa (吉川 峰夫, born 1947), Japanese basketball player
 
Fictional characters
- Joseph Mineo, fictional character on the HBO drama Oz
 
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