Mossel is a surname. Notable people with the surname include:
- Elchanan Mossel, professor of mathematics at the Massachusetts Institute of Technology
 - Hans Mossel (1905–1944), Dutch clarinettist and saxophonist
 - Jacob Mossel (1704–1761), Governor-General of the Dutch East Indies from 1750 to 1761
 
See also
- Mossel Bay, a harbour town on the Southern Cape of South Africa
 - Mossel Bay pincushion (Leucospermum praecox), evergreen rounded upright shrub
 - Mossel Bay Commando, light infantry regiment of the South African Army
 - Mossel Bay Local Municipality in the Western Cape Province of South Africa
 - Mosel (disambiguation)
 
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