Ponce is a surname or part of a surname. Notable people with the surname include:
Chilean people
- Miguel Ponce (born 1971), Chilean footballer
 - Waldo Ponce (born 1982), Chilean footballer
 - Walter Ponce (born 1998), Chilean footballer
 
Filipino people
- Juan Ponce Enrile (born 1924), Filipino politician and senator
 - Juan Ponce Sumuroy (fl. 1649-1650), Filipino rebel leader
 - Mariano Ponce (1863–1918), Filipino physician and leader of the Propaganda Movement
 
Mexican people
- Daniel Ponce de León (born 1980), Mexican professional boxer
 - Edgar Ponce (1974–2005), Mexican actor and dancer
 - Ernesto Zedillo (in full: Ernesto Zedillo Ponce de León) (born 1951), President of Mexico 1994–2000
 - Manuel Barbachano Ponce (1924–1994), Mexican film producer, director, screenwriter, and novelist
 - Manuel Ponce (1882–1948), Mexican composer
 - Miguel Ángel Ponce (born 1989), Mexican footballer
 - Sergio Amaury Ponce (born 1981), Mexican football (soccer) player
 
Puerto Rican people
- Carlos Ponce (born 1972), Puerto Rican actor, singer, and composer
 - Juan Ponce de Leon II (1524–1591), first Puerto Rican to assume governorship of Puerto Rico
 - Juan Ponce de León y Loayza, the great-grandson of Spanish conquistador Juan Ponce de Leon and founder of the city of Ponce in Puerto Rico
 
Spanish people
- Antonio Ponce de Santa Cruz, Spanish cartographer, instrument maker and historian.
 - Angela Ponce, first transgender woman in Miss Universe
 - Juan Ponce de León (1460–1521), Spanish explorer and conquistador of the New World
 - Luis Ponce de León (1527–1591), Spanish poet and Augustinian friar
 - Mateo de la Mata Ponce de León ([?]–1720), Spanish colonial officer, interim viceroy of Peru 1716
 - Pedro Ponce de León (1520–1584), Spanish Benedictine monk, established a school for the deaf
 
Other people
- Cecilia Ludmila Ponce, Argentine actress on Mexican Telenovelas
 - Cody Ponce, American baseball player
 - Dan Ponce, American television journalist
 - Ezequiel Ponce, Argentine footballer
 - Phil Ponce, American television journalist
 - Camilo Ponce Enríquez (politician) (1912–1976), President of Ecuador 1956–1960
 - Gustavo Ponce (b. 1952), Venezuelan mathematician
 - Juan Federico Ponce Vaides (1889–1956), Guatemalan politician, acting president 1944
 - Manuel María Ponce Brousset (1874–1966), President of Peru for two days in 1966
 - Marcelino Ponce Martínez, Vice President of Honduras
 - María Ponce de Bianco (1924–1978), Argentine social activist
 - Ebontius also known as "Poncio", French saint and Bishop of Barbastro
 
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