Pope Adrian or Pope Hadrian may refer to:
- Pope Adrian I (772–795)
 - Pope Adrian II (867–872)
 - Pope Adrian III (884–885)
 - Pope Adrian IV (1154–1159)
 - Pope Adrian V (1276)
 - Pope Adrian VI (1522–1523)
 
Fiction:
- Hadrian the Seventh, novel and play featuring a fictional English Pope Hadrian VII
 
Music:
- Pope Adrian 37th Psychristiatric, concept album by Rudimentary Peni
 
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