The Protocol of St. Petersburg may refer to:
- Protocol of St. Petersburg (1826), an Anglo–Russian treaty about the Greek War of Independence
 - Protocol of St. Petersburg (1887), treaty of the Afghan Boundary Commission regarding Afghanistan's border with Russia
 - Protocol of St. Petersburg (1904), an international anti-anarchist treaty
 - Protocol of St. Petersburg (1913), a Bulgarian–Romanian treaty through which Bulgaria ceded Silistra to Romania
 
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