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SPIE is the Society of Photo-Optical Instrumentation Engineers, an international optical engineering society.
SPIE may also refer to:
- SPIE SA, a French industrial equipment company
- Special Patrol Insertion/Extraction, a military technique for insertion/extraction
- Spie Batignolles, France-based multinational engineering company
- SPIE Gold Medal, the highest honor of the International Society for Optics and Photonics
- SPIE Newsroom, a technical news website launched in March 2006
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