San Luca may refer to:
- San Luca, a comune in the Province of Reggio Calabria in the Italian region Calabria, Italy
- San Luca feud, a long-running conflict between two clans of the 'Ndrangheta
- San Luca, Venice, a church in the sestiere of San Marco in Venice, Italy
- Accademia di San Luca
See also
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