Sizemore is a family name. Notable people with the surname include:
- Barbara Sizemore (1927–2004), American educator and researcher
- Bill Sizemore (born 1951), American political activist
- Chris Costner Sizemore (1927–2016), American patient with multiple personality disorder
- Grady Sizemore III (born 1982), American professional baseball player
- Herschel Sizemore (1935–2022), American mandolinist
- James Sizemore (born 1978), American composer and orchestrator of film scores
- Jason Sizemore, American writer and editor
- Scott Sizemore (born 1985), American professional baseball player
- Susan Sizemore (1951–2020), American novelist
- Ted Sizemore (born 1945), American former professional baseball player
- Tom Sizemore (1961–2023), American actor
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