Slaughter is a surname.
Notable people having this surname include:
- Anne-Marie Slaughter (born 1958), President and CEO of New America, Former Dean of the Woodrow Wilson School of Public and International Affairs at Princeton University
 - Carolyn Slaughter (born 1946), writer
 - Christopher Columbus Slaughter (1837–1919), American rancher, cattle drover and breeder, banker and philanthropist in the Old West
 - Enos Slaughter (1916–2002), Hall of Fame baseball player
 - Fenton M. Slaughter (1826–1897), American politician
 - Frank G. Slaughter (1908–2001), novelist
 - Fred Slaughter (1942–2016), American basketball player and sports agent
 - Gabriel Slaughter (1767–1830), American politician, Governor of Kentucky
 - George Webb Slaughter (1811–1895), American Baptist minister, cattle breeder and drover, and rancher in Texas
 - James E. Slaughter (1813–1900), American Army lieutenant
 - Jim Slaughter (1928–1999), American professional basketball player
 - John Horton Slaughter (1841–1922), American lawman
 - Julia Cornelia Slaughter (1850–1905), American artist
 - Karin Slaughter (born 1971), writer
 - Louise Slaughter (1929–2018), American politician
 - Marcus Slaughter (born 1985), basketball player
 - Mark Slaughter (born 1964), lead singer of Slaughter (band)
 - Matthew J. Slaughter (born 1969), economist and Dean of the Tuck School of Business at Dartmouth College
 - Nugent Slaughter (1888–1968), special effects designer
 - Rebecca Slaughter (born c. 1983), acting chair of the Federal Trade Commission
 - Samuel Slaughter (1848–1910), American businessman; Washington state pioneer and politician
 - Sean Slaughter (born 1976), American Christian hip hop musician
 - Susan Slaughter, American orchestral trumpet player
 - Tracey Slaughter (born 1972), New Zealand writer and poet
 - Walter Slaughter (1860–1908), composer
 - Webster Slaughter (born 1964) American football player
 - William B. Slaughter (politician) (1797–1879), American politician
 - William B. Slaughter (rancher) (1852–1929), American rancher
 
See also
- Slaughter (disambiguation)
 - Sgt. Slaughter (born 1948), stage name of Robert Rudolph Remus, a pro wrestler
 
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