Topaloğlu is a Turkish surname, meaning son (-oğlu) of Topal. Notable people with the surname include:
- Ali Topaloğlu (born 1998), Turkish track and field athlete
 - Caner Topaloğlu (born 1985), Turkish basketball player
 - Perihan Topaloğlu (born 1987), Turkish female handball player
 - Yeliz Topaloğlu (born 1978), Turkish female football referee
 - Cihan Topaloğlu (born 1992), Turkish footballer
 
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