William Harper may refer to:
- William Harper (South Carolina politician) (1790–1847), US Senator from South Carolina
- William Rainey Harper (1856–1906), first president of the University of Chicago
- William Harper (Louisiana politician), state senator (African-American officeholders during and following the Reconstruction era)
- William Edmund Harper (1878–1940), Canadian astronomer
- Bill Harper (baseball) (1889–1951), Major League Baseball pitcher
- Bill Harper (footballer, born 1897) (1897–1989), Scottish football goalkeeper (Hibernian, Arsenal, national team)
- Billy Harper (footballer, born 1897) (1897–1982), English footballer
- Billy Harper (footballer, born 1877) (1877–1947), English footballer
- Bill Harper (footballer, born 1900) (1900–?), Scottish football goalkeeper (Sunderland, Crystal Palace)
- William Harper (Rhodesian politician) (1916–2006), Royal Air Force pilot and Rhodesian politician
- Billy Harper (born 1943), American jazz saxophonist
- William Claude Harper (born 1944), American jewelry artist
- William Harper (composer) (born 1949), American composer and photographer
- Bill Harper (soccer) (fl. 1968), Canadian soccer player (national team)
- Willie Harper (born 1950), former American football linebacker
- William Jackson Harper (born 1980), American actor
- William Harper Jr., pioneer aviator with the Wright brothers
- William Allen Harper, JFK assassination witness
- William A. Harper (1873–1910), Canadian-born artist
- Will Harper, a character on Eastenders
- Bill Harper, a character in Ambassador Bill
See also
- William Harpur (died 1574), merchant and Lord Mayor of London
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