Wolpe is a locational surname of German origin, named after the medieval County of Wölpe. It may refer to:
- AnnMarie Wolpe (1930-2018), South African sociologist, wife of Harold
 - Berthold Wolpe (1905–1989), German visual designer
 - David Wolpe (born 1958), American rabbi
 - Harold Wolpe (1926–1996), South African economist and husband of AnnMarie
 - Howard Wolpe (1939–2011), American politician
 - Irma Wolpe (1902–1984), Romanian-born composer
 - Joseph Wolpe (1915–1997), South African psychiatrist
 - Lenny Wolpe (born 1951), American actor
 - Paul Root Wolpe (born 1957), American sociologist
 - Sholeh Wolpé, Iranian-born American poet, literary translator and playwright
 - Shalom Dov Wolpo, also Sholom Ber Wolpe (born 1948), Israeli rabbi
 - Stefan Wolpe (1902–1972), American composer
 
See also
- Volpe
 - Wölpe, a river in Germany
 - County of Wölpe, a territorial lordship in the Middle Ages
 
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