List of target antigens in pemphigoid
Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
| Pemphigoid variant | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|---|---|---|
| Bullous pemphigoid | IgG, IgE[1] | NC16A terminal of BPAG2 BPAG1 | 180 230 |
| Gestational pemphigoid | IgG1 | NC16A terminal of BPAG2 BPAG1 | 180 230 |
| Cicatricial pemphigoid | C-terminal of BPAG2 | 180 | |
| Ocular cicatricial pemphigoid | Integrin beta-4 subunit | 200 | |
| Antiepiligrin cicatricial pemphigoid[nb 1] | Laminin 5 (Epiligrin, Laminin 332) | ||
| Linear IgA bullous dermatosis | LAD1 portion of BPAG2 Collagen type VII | 97 290/145 | |
| Protein 105 pemphigoid | Protein in lower lamina lucida | 105 |
Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:
| Disease | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|---|---|---|
| Epidermolysis bullosa acquisita | Collagen type VII | 290/145 | |
| Bullous lupus erythematosus | Collagen type VII | 290/145 | |
| Lichen planus pemphigoides[nb 2] | BPAG2 | 180 |
Footnotes
- ↑ The antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer.
- ↑ In this condition bullae develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus.
See also
References
- ↑ London, Vanessa A.; Kim, Gene H.; Fairley, Janet A.; Woodley, David T. (2012). "Successful Treatment of Bullous Pemphigoid with Omalizumab". Archives of Dermatology. 148 (11): 1241–1243. doi:10.1001/archdermatol.2012.1604. PMID 23165827.
- Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
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