Rifamycin

Rifamycin
Names
Trade namesAemcolo
Other namesRifamycin sodium
Clinical data
Drug classRifamycins[1]
Main usesTravelers' diarrhea[1]
Side effectsHeadache, constipation[1]
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Pregnancy
category
  • US: N (Not classified yet)
    Routes of
    use    		By mouth
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa619010
    Legal
    License data
    Legal status
    Chemical and physical data
    FormulaC37H47NO12
    Molar mass697.778 g·mol−1
    3D model (JSmol)
    SMILES
    • CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C
    InChI
    • InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
    • Key:HJYYPODYNSCCOU-ODRIEIDWSA-N

    Rifamycin, sold under the brand name Aemcolo, is an antibiotics used to treat travelers' diarrhea.[1] It is not recommended if a fever or bloody stool is present.[1] It is taken by mouth.[1]

    Common side effects include headache and constipation.[1] Other side effects may include Clostridium difficile associated diarrhea.[2] Safety in pregnancy and breastfeeding is unclear.[3] It is in the rifamycins class of medications.[1]

    Rifamycin was approved for medical use in the United States for treatment is 2018.[1] In the United States a course of treatment costs about 190 USD as of 2021.[4]

    Medical uses

    Dosage

    It is taken at a dose of 388 mg twice per day for three days.[1]

    References

    1. 1 2 3 4 5 6 7 8 9 10 "Rifamycin Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 17 October 2021.
    2. ↑ "DailyMed - AEMCOLO- rifamycin tablet, delayed release". dailymed.nlm.nih.gov. Archived from the original on 17 October 2021. Retrieved 17 October 2021.
    3. ↑ "Rifamycin (Aemcolo) Use During Pregnancy". Drugs.com. Archived from the original on 17 April 2021. Retrieved 17 October 2021.
    4. ↑ "Aemcolo Prices and Aemcolo Coupons - GoodRx". GoodRx. Retrieved 17 October 2021.
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