Singles
2022 Guanajuato Open
Champion	Zhu Lin
Runner-up	Rebecca Marino
Score	6–4, 6–1

Astra Sharma was the defending champion having won the previous edition in 2019,^[1] however she chose to participate at the 2022 BNP Paribas Open instead.

Zhu Lin won the title, defeating Rebecca Marino in the final, 6–4, 6–1.

Seeds

Draw

Finals

	Semifinals							Final
	1	Zhu Lin	6	6
		Anastasia Tikhonova	2	0
								1	Zhu Lin	6	6
								2	Rebecca Marino	4	1
		Carolina Alves	5	1
	2	Rebecca Marino	7	6

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	L Zhu	6	6
	Q	AP Martínez Mora	0	0				1	L Zhu	6	6
		D Vismane	4	1					Q Gleason	1	4
		Q Gleason	6	6											1	L Zhu	65	6	6
	Q	E Oosterhout	3	65											8	J Loeb	77	2	3
		K Volodko	6	77					K Volodko	4	77	4
		L Glushko	3	3				8	J Loeb	6	64	6
	8	J Loeb	6	6																		1	L Zhu	6	6
	LL	AM Becerra	6	61	63																		A Tikhonova	2	0
	WC	G Arangio	4	77	77			WC	G Arangio	1	1
		A Tikhonova	77	1	6				A Tikhonova	6	6
		F Contreras	64	6	2											A Tikhonova	6	6
	Q	D Hewitt	2	77	6										Q	D Hewitt	2	3
		M Zacarías	6	64	4			Q	D Hewitt	6	4	6
		F Di Lorenzo	6	6					F Di Lorenzo	3	6	4
	LL	S Schenck	0	0

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	R Anderson	6	3	6
		A Sutjiadi	4	6	2			5	R Anderson	4	2
	Q	Z Hitt	2	0					C Alves	6	6
		C Alves	6	6												C Alves	4	77	6
	Q	E Douglas	77	6											Q	E Douglas	6	65	1
	Q	K Christian	62	2				Q	E Douglas	7	5	6
	WC	CS Martínez Solís	0	1				4	A Hartono	5	7	0
	4	A Hartono	6	6																			C Alves	5	1
	7	V Grammatikopoulou	6	2	6																	2	R Marino	7	6
		P Plipuech	2	6	1			7	V Grammatikopoulou	2	1
	Q	MF Navarro	4	2					S Mendez	6	6
		S Mendez	6	6												S Mendez	5	1
		W Osuigwe	78	6											2	R Marino	7	6
	Q	J Hinojosa Gómez	66	3					W Osuigwe	1	2
	SE	A Reami	3	3				2	R Marino	6	6
	2	R Marino	6	6

References

• Main Draw