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Calderone is an Italian-language occupational surname. It is derived from the Vulgar Latin "caldaria" ("cauldron") and refers to the occupation of tinker.
The surname may refer to:
- Antonino Calderone (1935–2013), Sicilian Mafioso who turned state witness in 1987
 - Eric Calderone (born 1985), American guitarist and YouTuber
 - Giuseppe Calderone (1925–1978), influential Sicilian mafioso from Catania
 - Marina Elvira Calderone (born 1965), Italian politician
 - Mary Calderone (1904–1998), physician and public health advocate
 - Salvatore Calderone (1876-1929), American businessman
 - Victor Calderone (born 1967), house music producer and DJ from Brooklyn, New York
 - Angelina Calderone (born 1929 or 1930), grandmother of Lady Gaga and father of Joe Germanotta
- Jo Calderone, male alter ego of Lady Gaga
 
 
See also
- Calderone Concert Hall, defunct music venue in New York City
 - Calderone glacier in the Gran Sasso d’Italia mountain group in Abruzzo, Italy
 - Calderón
 
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