Lusutrombopag

Lusutrombopag
Names
Pronunciationloo" soo trom' boe pag
Trade namesMulpleta, Mulpleo, Lusutrombopag Shionogi, others
IUPAC name
  • (E)-3-[2,6-Dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid
Clinical data
Drug classThrombopoietin receptor agonist[1]
Main usesLow platelets due to chronic liver disease[2]
Side effectsHeadache, nausea, portal vein thrombosis, rash[2][3]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: N (Not classified yet)
    Routes of
    use    		By mouth
    Typical dose3 mg OD[1]
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa618043
    Legal
    License data
    Legal status
    • US: ℞-only
    • EU: Rx-only
    • In general: ℞ (Prescription only)
    Chemical and physical data
    FormulaC29H32Cl2N2O5S
    Molar mass591.54 g·mol−1
    3D model (JSmol)
    SMILES
    • CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC
    InChI
    • InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1 checkY
    • Key:NOZIJMHMKORZBA-KJCUYJGMSA-N checkY

    Lusutrombopag, sold under the brand name Mulpleta among others, is a medication used to treat low platelets due to chronic liver disease.[2] It is used before surgery.[1] It is taken by mouth.[1]

    Common side effects include headache.[2] Other side effects may include nausea, portal vein thrombosis, and rash.[3] It is a thrombopoietin receptor agonist which increases platelet numbers.[1][3]

    Lusutrombopag was approved in the United States in 2018 and Europe in 2019.[2][3] In the United Kingdom a course of treatment costs the NHS about £800.[1] In the United States this amount costs about 8,900 USD.[4]

    Medical uses

    Dosage

    It is taken as 3 mg per day for 7 days before surgery.[1]

    References

    1. 1 2 3 4 5 6 7 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1080. ISBN 978-0857114105.
    2. 1 2 3 4 5 "Lusutrombopag Monograph for Professionals". Drugs.com. Archived from the original on 17 June 2020. Retrieved 24 November 2021.
    3. 1 2 3 4 "Mulpleo EPAR". European Medicines Agency (EMA). Archived from the original on 17 June 2020. Retrieved 17 June 2020.
    4. ↑ "Mulpleta Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 April 2021. Retrieved 24 November 2021.
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