Niludipine
Names
Preferred IUPAC name
Bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Other names
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid bis(2-propoxyethyl) ester
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.041.003
EC Number
  • 245-120-6
MeSH C019497
UNII
  • InChI=1S/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3
    Key: VZWXXKDFACOXNT-UHFFFAOYSA-N
  • InChI=1/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3
    Key: VZWXXKDFACOXNT-UHFFFAOYAS
  • CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
Properties
C25H34N2O8
Molar mass 490.553 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Niludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.[1]


References

  1. ↑ Hashimoto, K (1979). "Effects of niludipine on the Cardiovascular system with a note on its Calcium-Antagonistic effects". Arzneimittel-Forschung. 29 (9): 1368–73. PMID 583243.


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