Amlodipine/benazepril

Amlodipine/benazepril
Combination of
AmlodipineCalcium channel blocker
BenazeprilACE inhibitor
Names
Trade namesLotrel
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    use    		By mouth
    External links
    AHFS/Drugs.comProfessional Drug Facts
    Legal
    License data
    Legal status

    Amlodipine/benazepril, marketed as Lotrel among others, is a medication used to treat high blood pressure.[1] It is a combination of amlodipine, a calcium channel blocker and benazepril, an angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1]

    Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1]

    The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2017, it was the 160th most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]

    Medical use

    It is used to treat high blood pressure.[1] It is not a first line treatment.[7]

    Cost

    A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2017, it was the 160th most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]

    References

    1. 1 2 3 4 5 6 7 8 9 "Amlodipine besylate and benazepril hydrochloride- amlodipine besylate and benazepril hydrochloride capsule". DailyMed. U.S. National Library of Medicine. Archived from the original on 17 May 2020. Retrieved 10 March 2019.
    2. ↑ Cerner Multum. "Amlodipine and benazepril Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 20 August 2016. Retrieved 10 March 2019.
    3. ↑ Bope, Edward T.; Kellerman, Rick D. (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 978-0-323-44335-7. Archived from the original on 2020-08-07. Retrieved 2020-07-11.
    4. 1 2 "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
    5. 1 2 "The Top 300 of 2020". ClinCalc DrugStats Database. ClinCalc LLC. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
    6. 1 2 "Amlodipine Besylate; Benazepril Hydrochloride - Drug Usage Statistics". ClinCalc DrugStats Database. ClinCalc LLC. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
    7. ↑ Faulkner MA, Hilleman DE (January 2001). "Amlodipine/benazepril: fixed dose combination therapy for hypertension". Expert Opinion on Pharmacotherapy. 2 (1): 165–78. doi:10.1517/14656566.2.1.165. PMID 11336577. S2CID 23021242.
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