Clidinium bromide

Clidinium bromide
Names
IUPAC name
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide
Clinical data
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Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    use    		By mouth
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa601036
    Legal
    Legal status
    Pharmacokinetics
    BioavailabilityLow
    ExcretionKidney and biliary
    Chemical and physical data
    FormulaC22H26NO3+
    Molar mass352.454 g·mol−1
    3D model (JSmol)
    SMILES
    • O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4
    InChI
    • InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1 checkY
    • Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N checkY

    Clidinium bromide is an anticholinergic (specifically a muscarinic antagonist) medication.[1] It may help symptoms of cramping and abdominal pain by slowing the intestines.

    In the United States it is only commercially available in combination with chlordiazepoxide (a benzodiazepine) as chlordiazepoxide/clidinium.[2]

    Mechanism of action

    Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions.[3]

    References

    1. ↑ "Clidinium bromide". Drugs.com. Archived from the original on August 28, 2018. Retrieved August 24, 2013.
    2. ↑ "Clidinium Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2018. Retrieved 5 January 2022.
    3. ↑ 2014 Nurses Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2014. pp. 245-6. ISBN 978-1-284-03115-7.
    Identifiers:
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