Oxotremorine

Oxotremorine
Clinical data
Pregnancy
category
  • C
Routes of
administration		Oral, intravenous
ATC code
  • none
Legal status
Legal status
  • US: Experimental/not yet approved
Identifiers
IUPAC name
  • 1-(4-Pyrrolidin-1-ylbut-2-yn-1-yl)pyrrolidin-2-one
CAS Number
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.662
Chemical and physical data
FormulaC12H18N2O
Molar mass206.289 g·mol−1
3D model (JSmol)
SMILES
  • C1CCN(C1)CC#CCN2CCCC2=O
InChI
  • InChI=InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2 ☒N
  • Key:RSDOPYMFZBJHRL-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Oxotremorine is a drug that acts as a selective muscarinic acetylcholine receptor agonist.[1]

Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.[2]

Oxotremorine also produces antipsychotic effects.[3]

References

  1. ↑ Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes". Biochemistry and Molecular Biology International. 29 (6): 1047–54. PMID 8330013. INIST 4025194.
  2. ↑ Craig CR, Stitzel RE, eds. (2004). Modern Pharmacology with Clinical Applications. Lippincott Williams & Wilkins. ISBN 978-0-7817-3762-3.
  3. ↑ Maehara S, Hikichi H, Satow A, Okuda S, Ohta H (November 2008). "Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia". Pharmacology, Biochemistry, and Behavior. 91 (1): 140–9. doi:10.1016/j.pbb.2008.06.023. PMID 18651995. S2CID 12225821. INIST 20678587.

See also

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