List of opioids

Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

Natural opiates

Opium alkaloids

Structures

Alkaloid salts mixtures

Semisynthetics including Bentley compounds

Morphine family

Structures of Morphine family
Morphine family
Chemical structure of 14-hydroxymorphine.14-Hydroxymorphine Chemical structure of 2,4-dinitrophenylmorphine.2,4-Dinitrophenylmorphine Chemical structure of 6-methyldihydromorphine.6-Methyldihydromorphine Chemical structure of 6-methylenedihydrodesoxymorphine.6-Methylenedihydrodesoxymorphine Chemical structure of 6-acetyldihydromorphine hydrochloride.6-Acetyldihydromorphine hydrochloride
Chemical structure of azidomorphine. Azidomorphine Chemical structure of chlornaltrexamine. Chlornaltrexamine Chemical structure of chloroxymorphamine. Chloroxymorphamine Chemical structure of desomorphine.Desomorphine
(Dihydrodesoxymorphine)
Chemical structure of dihydromorphine. Dihydromorphine
Chemical structure of ethyldihydromorphine. Ethyldihydromorphine Chemical structure of hydromorphinol. Hydromorphinol Chemical structure of methyldesorphine. Methyldesorphine Chemical structure of N-phenethylnormorphine. N-Phenethylnormorphine Chemical structure of 6-nicotinoyldihydromorphine.6-nicotinoyldihydromorphine
Chemical structure of RAM-378. RAM-378

3,6-diesters of morphine

Structures
3,6-diesters of morphine
Chemical structure of acetylpropionylmorphine. Acetylpropionylmorphine 3,6-Dibutanoylmorphine Chemical structure of diacetyldihydromorphine.Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Chemical structure of dibutyrylmorphine. Dibutyrylmorphine Chemical structure of dibenzoylmorphine. Dibenzoylmorphine Chemical structure of diformylmorphine. Diformylmorphine
Chemical structure of dipropanoylmorphine. Dipropanoylmorphine Chemical structure of heroin.Heroin
(diacetylmorphine)
Chemical structure of nicomorphine. Nicomorphine

Codeine-dionine family

Structures

Morphinones and morphols

Morphides

  • α-Chlorocodide (= chlorocodide) 
  • β-Chlorocodide 
  • α-Chloromorphide (= chloromorphide)
  • Bromocodide 
  • Bromomorphide 
  • Chlorodihydrocodide 
  • Chloromorphide
  • Codide 
Structures
Morphides
Chemical structure of alpha-chlorocodide. α-chlorocodide Chemical structure of beta-chlorocodide. β-chlorocodide Chemical structure of bromomorphide. Bromomorphide
Chemical structure of chlorodihydrocodide. Chlorodihydrocodide. Chemical structure of chloromorphide. Chloromorphide Chemical structure of codide. Codide

Dihydrocodeine series

Nitrogen morphine derivatives

Structures
Morphides
Chemical structure of 1-nitrocodeine. 1-Nitrocodeine Chemical structure of codeine-N-oxide. Codeine-N-oxide Chemical structure of morphine-N-oxide. Morphine-N-oxide

Hydrazones

Structures
Hydrazones
Chemical structure of oxymorphazone. Oxymorphazone

Halogenated morphine derivatives

  • 1-Bromocodeine 
  • 1-Chlorocodeine 
  • 1-Iodomorphine
Structures
Other open chain opioids
Chemical structure of 1-bromocodeine.

1-Bromocodeine

Chemical structure of 1-chlorocodeine.

1-Chlorocodeine

General structure of 1-iodomorphine.

1-Iodomorphine

Active opiate metabolites

Morphinans

Morphinan series

Structures
Other morphinans
Chemical structure of 4-chlorophenylpyridomorphinan 4-chlorophenylpyridomorphinan Chemical structure of cyclorphan. Cyclorphan Chemical structure of dextrallorphan. Dextrallorphan Chemical structure of levargorphan Levargorphan Chemical structure of levophenacylmorphan. Levophenacylmorphan
Chemical structure of levomethorphan Levomethorphan Chemical structure of norlevorphanol. Norlevorphanol Chemical structure of N-methylmorphinan. N-Methylmorphinan Chemical structure of oxilorphan. Oxilorphan Chemical structure of phenomorphan. Phenomorphan
Chemical structure of dextromethorphan. Dextromethorphan Chemical structure of Levomethorphan. levomethorphan Chemical structure of morphanol. Morphanol Chemical structure of Ro4-1539. Ro4-1539 Chemical structure of stephodeline. Stephodeline Chemical structure of xorphanol. Xorphanol

Others

Structures
Other Morphinans
Chemical structure of 1-nitroaknadinine 1-Nitroaknadinine Chemical structure of 14-episinomenine. 14-episinomenine Chemical structure of 5,6-dihydronorsalutaridine. 5,6-Dihydronorsalutaridine Chemical structure of 6-keto-nalbuphine 6-Keto Nalbuphine Chemical structure of aknadinine. Aknadinine
Chemical structure of butorphanol Butorphanol Chemical structure of cephakicine. Cephakicine Chemical structure of cephasamine. Cephasamine Chemical structure of cyprodime. Cyprodime Chemical structure of drotebanol. Drotebanol
Chemical structure of fenfangjine G. Fenfangjine G Chemical structure of nalbuphine. Nalbuphine Chemical structure of sinococuline. Sinococuline Chemical structure of sinomenine. Sinomenine Chemical structure of tannagine. Tannagine

Benzomorphans

4-Phenylpiperidines

Pethidines (meperidines)

Prodines

Ketobemidones

Others

Structures
Other phenylpiperidines
Chemical structure of alvimopan.Alvimopan Chemical structure of loperamide. Loperamide Chemical structure of LS-115509. LS-115509 General structure of picenadol. Picenadol

Open chain opioids

Amidones

Structures

Methadols

Structures
Other open chain opioids
Chemical structure of alphaacetylmethadol.

Alphaacetylmethadol

Chemical structure of fimepheptanol.

Dimepheptanol

General structure of levacetylmethadol.

Levacetylmethadol

Chemical structure of noracetylmethadol.

Noracetylmethadol

Moramides

Structures
Other open chain opioids
Chemical structure of Desmethylmoramide.

Desmethylmoramide

Chemical structure of Dextromoramide.

Dextromoramide

General structure of Levomoramide.

Levomoramide

General structure of Moramide intermediate.

Moramide intermediate

General structure of Racemoramide.

Racemoramide

Thiambutenes

Phenalkoxams

Structures
Phenalkoxams
Chemical structure of dextropropoxyphene.

Dextropropoxyphene
(propoxyphene)

Chemical structure of dimenoxadol.

Dimenoxadol

General structure of dioxaphetyl butyrate.

Dioxaphetyl butyrate

General structure of levopropoxyphene.

Levopropoxyphene

General structure of norpropoxyphene.

Norpropoxyphene

Ampromides

Structures

Others

Structures
Other open chain opioids
Chemical structure of embutramide.

Embutramide

Chemical structure of IC-26.

IC-26

Chemical structure of isoaminile.

Isoaminile

General structure of lefetamine.

Lefetamine

Chemical structure of R-4066.

R-4066

Anilidopiperidines

Oripavine derivatives

Thienorphine

Phenazepanes

Pirinitramides

Structures
Pirinitramides
Chemical structure of bezitramide.

Bezitramide

Chemical structure of piritramide.

Piritramide

Benzimidazoles

Structures

Indoles

Structures
Indoles
Chemical structure of 18-methoxycoronaridine.

18-Methoxycoronaridine

Chemical structure of 7-acetoxymitragynine.

7-Acetoxymitragynine

General structure of 7-hydroxymitragynine.

7-Hydroxymitragynine

General structure of akuammidine.

Akuammidine

General structure of akuammine.

Akuammine

General structure of eseroline.

Eseroline

General structure of hodgkinsine.

Hodgkinsine

General structure of mitragynine.

Mitragynine

General structure of pericine.

Pericine

General structure of pseudoakuammigine.

Pseudoakuammigine

Beta-Amino Ketones

  • 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one
Structures
Indoles
Chemical structure of beta-amine ketone 'compound 29'

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines

Structures
Diphenylmethylpiperazines
Chemical structure of BW373U86.

BW373U86

Chemical structure of DPI-221.

DPI-221

Chemical structure of DPI-287.

DPI-287

Chemical structure of DPI-3290.

DPI-3290

Chemical structure of SNC-80.

SNC-80

Opioid peptides

β-neoendorphin

Dynorphins

Structures
Dynorphins
Chemical structure of dermenkephalin. Big dynorphin Chemical structure of dynorphin A. Dynorphin A Chemical structure of dynorphin B. Dynorphin B

Endomorphins

  • Endomorphin-1
  • Endomorphin-2

Endorphins

  • α-Endorphin
  • β-Endorphin
  • γ-Endorphin
  • α-Neoendorphin
  • β-Neoendorphin
Structures
Dynorphins
Chemical structure of beta-endorphin. Beta-endorphin Chemical structure of alpha-endorphin. Alpha-endorphin Chemical structure of gamma-endorphin. Gamma-endorphin Chemical structure of α-neo-endorphin. α-neoendorphin Chemical structure of β-neo-endorphin. β-neoendorphin

Enkephalins

Structures
Enkephalins
Chemical structure of DADLE. DADLE Chemical structure of DAMGO. DAMGO Chemical structure of deltorphin. Deltorphin Chemical structure of Met-enkephalin. Met-enkephalin Chemical structure of Leu-enkephalin. Leu-enkephalin

Propeptides

Others / unknown

Structures
Other or unknown opioid peptides
Chemical structure of adrenorphin. Adrenorphin Chemical structure of amidorphin. Amidorphin Chemical structure of casomorphin. Casomorphin Chemical structure of DALDA. DALDA Chemical structure of deltorphin. Deltorphin
Chemical structure of dermorphin. Dermorphin Chemical structure of DPDPE. DPDPE Chemical structure of Endomorphin-1. Endomorphin-1
Chemical structure of Endomorphin-2. Endomorphin-2
Chemical structure of gliadorphin. Gliadorphin Chemical structure of morphiceptin. Morphiceptin
Chemical structure of nociceptin. Nociceptin Chemical structure of octreotide. Octreotide Chemical structure of opiorphin. Opiorphin Chemical structure of rubiscolin. Rubiscolin Chemical structure of TRIMU 5. TRIMU 5

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

Uncategorized opioids

Combination drug formulations containing opioids

See also

References

  1. ChemIndex CAS Registry Number 3371-56-0
  2. ChemIndex CAS Registry Number 509-56-8
  3. ChemIndex CAS Registry Number 63715-94-6
  4. NCBI PubChem SID 750205
  5. chembase cbid_346222
  6. Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.
  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740
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